Professor Francisco Xavier Castellanos
Hosted by School of Psychology and the Queensland Brain Institute, University of Queensland.
4- 5 p.m 20th August, Room 302, McElwain Building, School of Psychology, St Lucia.
Consistent Inconsistency: Variability, Functional Connectivity, and ADHD - Work in Progress
Francisco Xavier Castellanos, M.D.
Neidich Professor of Child and Adolescent Psychiatry
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience NYU Child Study Center, NYU School of Medicine Research Psychiatrist, Nathan Kline Institute for Psychiatric Research
In searching for quantitative phenotypes for ADHD, we are focusing on increased intra-individual variability in response times and in spontaneous brain activity (resting state networks) which denotes functionally connected regions. At rest, we have found preliminary evidence of a new candidate locus of dysfunction that includes the precuneus and posterior cingulate cortex. We are also pursuing a novel genetic linkage in 4q13 with the eventual goal of determining whether it is even more strongly associated to intermediate phenotypes.
Professor Castellanos is a world-authority on the neuroscience of ADHD. His 2002 Nature Reviews Neuroscience paper with Rosemary Tannock on the endophenotype approach to ADHD, provided a conceptual framework for understanding the biological pathways that might lead from gene to disorder in ADHD. The research of Professor Castellanos spans structural and functional euroimaging, genetics and cognitive neuroscience and he has been instrumental in theoretical
development within the field.